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5–four ?mol/L variety,[156][157] the concentration of serotonin in synaptic vesicles was calculated at 270 mM.[182] Following vesicular release, the ensuing focus of serotonin in the synaptic cleft, to which serotonin receptors are exposed, is approximated to generally be about 300 ?mol/L. So, while in vitro receptor binding affinities, efficac
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